Journal: Neurology International

Article Title: Pain and the Brain: A Systematic Review of Methods, EEG Biomarkers, Limitations, and Future Directions

doi: 10.3390/neurolint17040046

Figure Lengend Snippet: Summary of study features, methods, findings, and limitations.

Article Snippet: Beck B et al. (2019) [ ] , Nociceptive laser–evoked potentials Non–nociceptive electrical somatosensory–evoked potentials GBO components , Two–tailed one–sample t -test, two–tailed paired–sample t - test, paired–sample t -test Pearson correlation tests Spearman’s rank order method , Time–domain analysis: single–trial peak N2 and P2 amplitudes Frequency–time domain: cluster–based permutation test, average power|signal detection theory: perpetual sensitivity, bias , Laser–evoked N1, N2, and P2 waves responded according to stimulus intensity (compared to electrical stimulation) Laser–evoked N2 wave showed variability in pain perception , Can not conclude that the effects are exclusive to nociceptive processing Other stimulus types not tested Time interval of the electrical stimuli may have prevented assessment of components in the A–beta lemniscal pathway..

Techniques: Activity Assay, Transformation Assay, Control, Injection, Mann-Whitney U-Test, Comparison, Plasmid Preparation, Biomarker Discovery, Functional Assay, Activation Assay, Imaging, Inhibition, Derivative Assay, Sampling, Medications, Selection, Standard Deviation

Journal: Journal of Cerebral Blood Flow & Metabolism

Article Title: Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge

doi: 10.1177/0271678X211015101

Figure Lengend Snippet: Overview of quantification and statistical methods.

Article Snippet: 5 a , Logan graphical approach (unweighted) , Reference region : Whole cerebellum from MNI structural atlas, thresholded at 90% Smoothing : Dynamic PET data smoothing with 8 mm FWHM Gaussian kernel Partial volume correction : None Implementation : t * defined from preliminary region-based analysis of subcallosal area (Harvard-Oxford atlas) as high-binding region and fixed at 27 minutes after injection , In-house MATLAB code , Smoothing : 5 mm variance smoothing Type : non-parametric Description : paired t-test (N permutation = 10,000) and threshold-free cluster enhancement Multiple comparison correction : FWE , FSL - Randomise.

Techniques: Software, Injection, Comparison, Derivative Assay, Activity Assay